Antithrombin (formerly known as Antithrombin III) is a major natural anticoagulant. It inhibits several activated clotting factors, most importantly thrombin (IIa) and Factor Xa. Its activity is dramatically increased by heparin, which is why heparin is used as a drug. Hereditary Antithrombin deficiency is an autosomal dominant disorder that significantly increases the risk of venous thromboembolism (deep vein thrombosis and pulmonary embolism). It is one of the strongest thrombophilic risk factors. Patients with this deficiency often present with thrombosis at a young age, have a family history, and may experience thrombosis in unusual sites. Diagnosis is made by measuring antithrombin activity (functional assay) and antigen level. Treatment involves long-term anticoagulation and careful management during high-risk situations like surgery or pregnancy.

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Zambia

• loveness Phiri – 1084 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies