Differentiating Essential Thrombocythemia (a myeloproliferative neoplasm) from reactive thrombocytosis (a secondary response to conditions like infection, inflammation, or iron deficiency) is crucial. While both have high platelet counts, the bone marrow findings are distinct. In reactive thrombocytosis, the bone marrow shows a simple increase in the number of normal, mature megakaryocytes. In Essential Thrombocythemia, the bone marrow biopsy reveals characteristic morphological abnormalities: the megakaryocytes are often increased in number, but they are large, clustered, and have hyperlobulated (staghorn) nuclei. These atypical megakaryocytes are a key diagnostic feature of ET according to the WHO classification. Molecular testing for the JAK2 V617F mutation is also a major diagnostic criterion for ET.

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Zambia

• Joseph Soko – 101 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies