True. The TSC1/TSC2 complex acts as a GTPase-activating protein (GAP) for the small G-protein Rheb, keeping it in its inactive GDP-bound state. AKT, when activated by the PI3K pathway, phosphorylates TSC2 (a component of the complex). This phosphorylation inhibits the GAP activity of the TSC1/TSC2 complex. As a result, Rheb accumulates in its active GTP-bound form. Active Rheb-GTP directly binds to and activates mTORC1, stimulating protein synthesis and cell growth.

Break down complex topics into smaller, manageable chunks for easier recall.

Zambia

• ivwananji siwale – 29 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies