The ABO Blood Group System
Q: What does the term 'subgroup' refer to in the context of the ABO system?
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The WNT receptor is a complex of a Frizzled family protein (a 7-transmembrane receptor) and a LRP5/6 co-receptor. When a WNT ligand binds to this complex, it initiates a conformational change that recruits the cytoplasmic adapter protein Dishevelled (DVL). This recruitment is the first step in inactivating the β-Catenin destruction complex.
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