Leukocyte reduction (or leukoreduction) is the process of removing most of the white blood cells (leukocytes) from a blood product by filtration. The primary reasons are to prevent or reduce: 1) Febrile non-hemolytic transfusion reactions (FNHTR): These are common reactions characterized by fever and chills during transfusion, often caused by cytokines released from donor leukocytes or recipient antibodies reacting to donor leukocytes. 2) HLA alloimmunization: Exposure to donor leukocytes can cause the recipient to develop antibodies against Human Leukocyte Antigens (HLA). This is a particular concern for patients who will need long-term platelet support (like leukemia patients), as HLA antibodies can make them refractory to random donor platelets. 3) Transmission of cell-associated viruses like CMV and HTLV. While leukoreduction helps with these, it is not primarily for preventing bacterial contamination (which comes from the skin or donor) or ABO reactions.

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Zambia

• ivwananji siwale – 29 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies