Tax interferes with multiple DNA repair pathways. A well-documented mechanism is its inhibition of base excision repair (BER). Tax binds to and inactivates DNA polymerase β (Pol β), a key enzyme in the BER pathway that is responsible for repairing small, non-bulky DNA lesions like oxidized bases. By crippling this repair mechanism, Tax allows DNA damage to accumulate, leading to increased mutation rates and genomic instability, which fuels the transformation process towards Adult T-cell Leukemia/Lymphoma (ATLL).

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Zambia

• loveness Phiri – 1084 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies