Transfusion Reactions and Compatibility Testing
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The TGF-β-activated SMAD complex (SMAD2/3-SMAD4) can either activate or repress transcription depending on the cellular context and co-factors. For repression, a common mechanism involves recruiting co-repressors like Ski (Sloan-Kettering Institute proto-oncogene) and SnoN. These proteins recruit histone deacetylases (HDACs) to modify chromatin and silence the expression of target genes, such as c-Myc.
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