Antimicrobial and Antifungal Chemotherapy

This critical topic within Pharmacology and Toxicology addresses the use of drugs to treat bacterial and fungal infections. It covers the principles of chemotherapy, including selective toxicity, antimicrobial classification based on mechanism and spectrum, and key concepts like MIC and MBC. The module provides an in-depth analysis of major antibacterial drug classes such as beta-lactams, aminoglycosides, macrolides, tetracyclines, quinolones, and sulfonamides, detailing their mechanisms of action, clinical uses, and adverse effects. It also comprehensively covers antifungal agents, including polyenes, azoles, echinocandins, and allylamines. For Zambian university and college students in pharmacology, medicine, and laboratory science programs, this knowledge is vital for combating infectious diseases and addressing antimicrobial resistance. Mastery of this topic is essential for success in tertiary-level examinations and for informed therapeutic decision-making in clinical practice across Zambia's healthcare system.