Autacoids, Inflammation & NSAIDs

This comprehensive topic explores autacoids (local hormones like histamine, serotonin, prostaglandins, leukotrienes), the inflammatory process, and the pharmacology of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). For Zambian college and university students in medical and health science programs, this knowledge is vital for managing common conditions such as allergies, pain, fever, rheumatoid arthritis, and gout. The module delves into the synthesis and actions of inflammatory mediators, the mechanism of action of NSAIDs via cyclooxygenase inhibition, and the differences between traditional NSAIDs and COX-2 selective inhibitors. Students will also learn about the therapeutic uses, major adverse effects (especially gastrointestinal, renal, and cardiovascular), and contraindications of these drugs. Understanding this subject is crucial for Zambian learners to make informed therapeutic choices in a setting where inflammatory and pain-related diseases are prevalent. It is a key component of the syllabus for pharmacology examinations and clinical practice.