Bilirubin Metabolism and Differential Diagnosis of Jaundice
Q: Which of the following are steps in bilirubin metabolism?
Did You Know?
True. pRb (retinoblastoma protein) normally binds and inhibits E2F transcription factors, preventing S-phase gene expression. The HPV E7 protein binds to pRb, displacing E2F and targeting pRb for degradation. This releases E2F, allowing the cell to inappropriately enter the DNA synthesis (S) phase of the cell cycle, a key step in HPV-induced carcinogenesis.
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