Calcium Homeostasis and Parathyroid Hormone

This topic delves into the endocrine regulation of calcium and phosphate metabolism, a key subject for tertiary students in Zambia studying clinical biochemistry or endocrinology. It focuses on the roles of Parathyroid Hormone (PTH), Vitamin D (Calcitriol), and calcitonin in maintaining serum calcium levels. Students will explore the actions of PTH on bone, kidney, and intestine, the synthesis and activation of Vitamin D, and the pathophysiology of disorders such as hypercalcaemia and hypocalcaemia. A solid grasp of this hormonal axis is crucial for passing advanced biochemistry examinations and for clinical practice in Zambia, where bone and mineral disorders are prevalent. This knowledge is foundational for careers in clinical chemistry and endocrinology.