Cancer Immunotherapy
Q: What is a major challenge in using tumor-infiltrating lymphocytes (TILs) for adoptive cell therapy?
Did You Know?
True. This is the principle of class switching. After activation by antigen and T cell help, a B cell can undergo a DNA recombination event that changes the constant region (isotype) of the antibody it produces (e.g., from IgM to IgG) while keeping the same variable region and, therefore, the same antigen-binding specificity.
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