Cell Signaling Pathways in Disease

Cell Signaling Pathways in Disease is an advanced topic for tertiary students in Molecular Biology, Cancer Biology, and Biomedical Sciences programs in Zambian universities. This module examines key signaling cascades such as the Mitogen-Activated Protein Kinase (MAPK) pathway and the Phosphoinositide 3-Kinase (PI3K)/Akt pathway. Students will learn about normal signal transduction, mechanisms of dysregulation (e.g., mutations, overexpression), and implications in oncogenesis, diabetes, and other diseases. The topic integrates knowledge of receptor tyrosine kinases, second messengers, transcription factors, and targeted therapies. Proficiency in cell signaling is essential for careers in biomedical research, oncology, drug development, and molecular diagnostics in Zambia. This subject is critical for university examinations, research projects, and professional advancement, preparing learners to engage with cutting-edge science and contribute to Zambia's growing biomedical sector.