Ivermectin is a broad-spectrum antiparasitic agent derived from the bacterium Streptomyces avermitilis. Its primary mode of action is by binding selectively and with high affinity to glutamate-gated chloride ion channels, which are found in nerve and muscle cells of invertebrates. This binding increases the permeability of the cell membrane to chloride ions, leading to hyperpolarization of the nerve or muscle cell. This hyperpolarization results in paralysis and death of the parasite. Importantly, mammalian glutamate-gated chloride channels are located only in the central nervous system, and ivermectin does not cross the blood-brain barrier easily at therapeutic doses, making it safe for human use. It is highly effective against many nematodes (roundworms) and ectoparasites but has little to no effect on cestodes (tapeworms) or trematodes (flukes).

Break down complex topics into smaller, manageable chunks for easier recall.

Zambia

• Naomi Miselo – 31 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies