University revision · Hematology

Chronic Lymphoid Leukaemias

Question 1 of 5 Course: Biomedical Science(Degree)

Which type of leukemia is characterized by the presence of cells with 'hairy' cytoplasmic projections and is strongly positive for the tartrate-resistant acid phosphatase (TRAP) stain?

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This statement is false. Prostate cancer has a strong and characteristic predilection for metastasizing to bones, not the liver. The axial skeleton, particularly the lumbar spine, pelvis, ribs, and femur, is the most common site of distant metastasis. These bone metastases are typically osteoblastic (bone-forming), appearing as dense, sclerotic lesions on imaging. Hematogenous spread to the liver, lungs, and other organs does occur, but this is generally later in the disease course. The unique tropism for bone is thought to be due to the 'seed and soil' hypothesis, where prostate cancer cells (seed) find a favorable microenvironment in the bone marrow (soil). Bone pain, especially in the back, is a classic symptom of metastatic prostate cancer.

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Chronic Myeloid Leukaemia

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