This statement is true. Reagent red cells (A1 and B cells) used in reverse grouping have a limited shelf life, typically around 30-40 days when stored properly at 2-8°C. As they age, the cells can become fragile, and the antigen expression on their surface can deteriorate. If expired or mishandled reagent cells are used, they may not agglutinate properly, even when mixed with the appropriate antibody in the patient's serum. This would lead to a false-negative reaction. For example, a type A patient's serum (containing anti-B) might fail to agglutinate expired B cells, making it appear as if the patient lacks anti-B. This would cause a discrepancy with forward grouping. This is why daily quality control with known sera is essential to verify the reactivity of reagent cells, and why strict inventory control of expiration dates is a must in the blood bank.

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Zambia

• loveness Phiri – 1084 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies