The GLI family of zinc-finger transcription factors (GLI1, GLI2, GLI3) are the final mediators of Hedgehog signaling. In the canonical pathway, activation of SMO leads to the conversion of full-length GLI proteins into their transcriptional activator forms, which then enter the nucleus and regulate the expression of target genes involved in cell proliferation and stemness.

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Zambia

• Joseph Soko – 101 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies