Definition and Causes of Upper GI Bleeding
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Three examples: 1) **Aspirin** – inhibits platelet aggregation (increasing bleeding risk) and displaces warfarin from protein binding sites. 2) **Antibiotics (e.g., ciprofloxacin)** – inhibit vitamin K production by gut flora and may inhibit warfarin metabolism. 3) **Amiodarone** – inhibits CYP2C9, slowing warfarin metabolism and increasing its effect.
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