Digital Evidence & Cybercrimes
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Lubricant gel contamination is a common artifact in urine cytology that can mimic malignancy. The gel appears as amorphous, basophilic globular material that may overlay cells, creating pseudonuclear inclusions or obscuring cellular details. It is often introduced during catheterization or cystoscopy. Other artifacts include starch granules (from gloves), talc, or mucus strands. Recognizing these contaminants prevents misinterpretation as signet-ring cells, intracellular inclusions, or mucinous material from adenocarcinoma. Clinical history of instrumentation and characteristic appearance help identify lubricant gel artifacts.
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