Economic Impact of Hookworm Disease
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The Papanicolaou (Pap) stain is the preferred method for routine urine cytology due to its excellent nuclear detail and cytoplasmic differentiation. This stain provides clear visualization of chromatin patterns, nuclear membranes, and cytoplasmic characteristics essential for distinguishing benign from malignant cells. The Pap stain's ability to highlight subtle nuclear abnormalities makes it particularly valuable for detecting high-grade urothelial carcinoma and carcinoma in situ. While other stains may be used for specific purposes, Pap staining remains the gold standard for diagnostic urine cytology in clinical practice.
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