University revision · Clinical Biochemistry

Endocrine Biochemistry and Hormonal Disorders

Question 1 of 10 Course: Biomedical Science(Degree)

Which of the following hormones decreases basal metabolic rate when levels are low?

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The TSC1/TSC2 complex acts as a GTPase-activating protein (GAP) for the small G-protein Rheb. In its active state, it keeps Rheb in its inactive GDP-bound form. When AKT phosphorylates and inhibits TSC2, Rheb is allowed to switch to its active GTP-bound state. Active Rheb-GTP directly activates mTORC1, the complex that stimulates protein synthesis, cell growth, and metabolism.

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