The HCV Core protein has been shown to dysregulate the Wnt/β-catenin pathway, a key driver in many HCCs. The Core protein can stabilize β-catenin by inhibiting its degradation, often through interactions with GSK-3β or other components of the destruction complex. This leads to accumulation of β-catenin in the nucleus and activation of Wnt target genes that promote cell proliferation and survival. This direct interference with a major oncogenic pathway, combined with chronic inflammation, contributes to HCV-associated hepatocarcinogenesis.

Break down complex topics into smaller, manageable chunks for easier recall.

Zambia

• loveness Phiri – 1084 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies