Gene Expression: Transcription and Translation
Q: What is the term for the process where different mRNA molecules are produced from the same gene by including different combinations of exons?
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ABO-related Hemolytic Disease of the Fetus and Newborn (HDFN) occurs when a mother with IgG antibodies against her fetus's ABO antigens transfers these antibodies across the placenta, leading to destruction of the fetal red cells. The most common scenario is a type O mother (who has IgG anti-A and anti-B) with a type A or B baby. Therefore, a type AB mother is at the lowest risk. This is because a type AB mother has neither anti-A nor anti-B antibodies in her plasma. Without these antibodies, she cannot mount an immune attack against her baby's red cells, regardless of the baby's ABO type inherited from the father. While ABO HDFN is generally milder than Rh disease, it is still a common cause of neonatal jaundice.
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