Gout and Hyperuricaemia

This topic addresses the biochemistry and clinical aspects of purine metabolism disorders, focusing on hyperuricaemia and gout. It is highly relevant for tertiary students in Zambia pursuing studies in clinical biochemistry, rheumatology, or internal medicine. The curriculum covers the pathogenesis of gout, including uric acid crystal formation, the biochemical tests used for diagnosis (serum uric acid, synovial fluid analysis), and the associated risk factors such as diet, alcohol intake, and renal function. For Zambian college and university learners, understanding this condition is important for both examination success and clinical practice, as gout is a common and painful arthritis. This topic prepares graduates to assist in the diagnosis and understanding of metabolic arthritides in hospital and outpatient settings.