Target site modification is a resistance mechanism where mutations in genes encoding ribosomal proteins or RNA alter the drug-binding site. For example, mutations in the 23S rRNA can prevent macrolides like erythromycin from binding, rendering the antibiotic ineffective.

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Zambia

• Joseph Soko – 101 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies