Tax is a potent transcriptional activator. A key oncogenic mechanism is its ability to constitutively activate the NF-κB signaling pathway. Tax interacts with and activates the IKK complex, leading to persistent degradation of IκB and nuclear translocation of NF-κB. This drives the expression of genes that promote T-cell proliferation and survival, such as IL-2 and its receptor, and inhibits apoptosis.

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Zambia

• loveness Phiri – 1084 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies