Integrated Control of Neglected Tropical Diseases
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mTORC1 activation promotes anabolic processes: it stimulates protein synthesis by phosphorylating S6K1 and 4E-BP1, promotes lipid synthesis, and inhibits autophagy (a catabolic process). It does NOT directly stimulate apoptosis; in fact, it promotes cell survival. Apoptosis is typically inhibited by pathways like PI3K/AKT.
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