PDK1 (3-phosphoinositide-dependent protein kinase-1) is a key kinase that acts downstream of PIP3. It contains a PH domain that binds to PIP3 at the plasma membrane, bringing it into proximity with its substrates. The primary and essential function of PDK1 is to phosphorylate AKT on a critical threonine residue (Thr308) within its activation loop. This phosphorylation is a crucial step for partial activation of AKT. Full activation typically requires a second phosphorylation on Ser473 by mTORC2.

Break down complex topics into smaller, manageable chunks for easier recall.

Zambia

• Chita katowando – 271 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies