University revision · Laboratory Management

Laboratory Safety & Biosafety in Virology

Question 1 of 11 Course: Biomedical Science(Degree)

In the context of laboratory safety, what does the term 'BSL-4' refer to?

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In the early stages of carcinogenesis, TGF-β acts as a potent tumor suppressor by inducing cell cycle arrest and apoptosis. A critical step in cancer progression is the acquisition of resistance to this growth-inhibitory effect. This often occurs through mutations that inactivate components of the TGF-β signaling pathway, such as TGFBRII, SMAD4, or SMAD2, allowing the cells to proliferate unchecked.

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