Medical Genetics and Cancer

This topic covers the fundamental principles of medical genetics with a specific focus on the genetic basis of cancer, including oncogenes, tumor suppressor genes, and the role of mutations in carcinogenesis. Designed for Zambian university and college students pursuing diplomas or degrees in biomedical sciences, laboratory technology, or medicine, this module provides a deep understanding of how genetic alterations contribute to malignancies such as leukemia, retinoblastoma, and colon carcinoma. Students will explore the mechanisms of gene activation, DNA damage repair, apoptosis, and the implications of genetic instability. Mastery of this topic is essential for success in tertiary examinations and for future careers in clinical genetics, oncology research, or diagnostic pathology within Zambia’s healthcare and academic institutions. The content is aligned with advanced diploma and degree-level curricula, emphasizing both theoretical knowledge and practical relevance to improve diagnostic and therapeutic approaches in cancer care.