Molecular Basis of Cancer (Oncogenesis)

Delve into the fundamental molecular mechanisms that drive carcinogenesis, a central topic for tertiary students in Molecular Biology, Medical Genetics, and Biomedical Sciences across Zambian universities. This advanced module explores the multi-step process of cancer development, focusing on the genetic damage to four key regulatory gene classes: proto-oncogenes, tumor suppressor genes, apoptosis regulators, and DNA repair genes. You will gain a deep understanding of critical concepts such as signal transduction pathways, dysregulation of the cell cycle controlled by cyclins and CDKs, and the hallmarks of cancer including self-sufficiency in growth signals, evasion of apoptosis, and genomic instability. Detailed study of major oncogenes like RAS and MYC, and tumor suppressor genes like RB and p53, is essential. This knowledge is not only vital for passing your examinations but is also the cornerstone for understanding targeted cancer therapies and diagnostic techniques, preparing you for careers in genetic counseling, research, and molecular diagnostics within the Zambian health sector.