Neuropharmacology of Antipsychotics and Antidepressants

This topic explores the advanced pharmacology of antipsychotic and antidepressant medications used in tertiary-level mental health care. It covers the mechanisms of action, including receptor binding profiles such as D2, 5-HT2A, and others, and their clinical implications for conditions like schizophrenia, bipolar disorder, and major depression. Zambian university and college students will gain a deep understanding of first-generation versus second-generation antipsychotics, their side-effect profiles, and the management of extrapyramidal symptoms, hyperprolactinemia, and metabolic effects. The topic also delves into antidepressant classes, including SSRIs, SNRIs, TCAs, and MAOIs, focusing on their pharmacokinetics, therapeutic applications, and adverse effects. Emphasis is placed on evidence-based prescribing, monitoring parameters, and patient-centered care within the Zambian tertiary healthcare context. Mastery of this topic is essential for success in medical and pharmacy degree examinations, professional licensing, and clinical practice in Zambia's hospitals and community settings.