Oncogenes and Tumor Suppressor Genes

Oncogenes and tumor suppressor genes are pivotal concepts in cancer genetics for Zambian tertiary students studying biomedical sciences, oncology, and medical genetics. This topic delves into the normal roles of proto-oncogenes and tumor suppressor genes, their activation or inactivation mechanisms, and how mutations in these genes drive carcinogenesis. Students will examine key examples such as RAS, MYC, RB1, TP53, BRCA1, and BRCA2, understanding their functions in cell cycle regulation, apoptosis, and DNA repair. The material aligns with advanced diploma and degree curricula in Zambia, preparing learners for examinations and research in molecular oncology. This knowledge is crucial for careers in cancer research, genetic counselling, and clinical diagnostics, enabling Zambian graduates to contribute to the understanding and management of cancer, a growing public health concern in Zambia and across Africa.