Pediatrics: Inborn Errors of Metabolism Screening
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Zileuton is a 5-lipoxygenase inhibitor. 5-lipoxygenase is the key enzyme that converts arachidonic acid into leukotrienes (LTB4, LTC4, LTD4, LTE4). Leukotrienes are potent mediators of bronchoconstriction, inflammation, and mucus secretion in asthma. By inhibiting their production, zileuton reduces asthma symptoms.
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