Pharmacology of General Anaesthetics

This advanced topic explores the principles, pharmacokinetics, and clinical use of general anaesthetic agents, tailored for tertiary students in Zambian medical, pharmacy, and anaesthesia technology programs. It covers the stages of anaesthesia, the concept of Minimum Alveolar Concentration (MAC), and the factors influencing the onset and recovery from anaesthesia, such as blood-gas partition coefficients. Students will compare and contrast different agents, including inhalational gases (nitrous oxide, halothane) and intravenous drugs (thiopentone, propofol, ketamine), focusing on their mechanisms, cardiovascular/respiratory effects, and specific adverse reactions. This knowledge is critical for safe perioperative patient management and is a key component of professional examinations for clinical degrees, ensuring Zambian graduates are prepared for roles in operating theatres and critical care settings.