Pharmacology of General and Local Anaesthetics

This topic provides a comprehensive overview of general and local anaesthetic agents for Zambian tertiary students in medical, dental, and anaesthesia programs. It explores the pharmacokinetics and pharmacodynamics of inhaled agents like halothane, sevoflurane, and nitrous oxide, and intravenous agents such as propofol and etomidate, including their effects on various organ systems and specific contraindications (e.g., in COPD). For local anaesthetics, the syllabus covers mechanism of action, factors affecting onset and duration, toxicity profiles, and the role of adjuvants like epinephrine. This knowledge is crucial for university and diploma students aiming to pass professional exams and for safe clinical practice in surgical and procedural settings across Zambia. A solid understanding ensures learners can contribute to safe anaesthesia delivery, a key component of surgical care in Zambian hospitals and clinics.