Pharmacology of Lignocaine and Bupivacaine
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Patients with asthma, nasal polyps, and sinusitis are at high risk for aspirin-exacerbated respiratory disease (AERD). Aspirin and other NSAIDs that inhibit COX-1 can trigger severe bronchospasm in these individuals by shunting arachidonic acid metabolism toward leukotriene production.
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