In HS, defects in proteins like spectrin or ankyrin weaken the connection between the cell membrane and its internal skeleton. As the cell circulates, especially through the spleen, it loses pieces of its membrane. This loss of surface area makes the cell round into a sphere, which is rigid and gets trapped in the spleen.

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Zambia

• Joseph Soko – 101 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies