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This statement is true. Sertoli cell tumors are rare sex cord-stromal tumors that arise from the supporting (Sertoli) cells of the seminiferous tubules. A significant proportion of these tumors are hormonally active and can produce estrogens. In a male, excess estrogen can lead to feminizing effects, the most common being gynecomastia (benign enlargement of breast tissue). Other signs may include loss of libido and testicular atrophy. While most Sertoli cell tumors are benign, about 10-20% exhibit malignant behavior with potential for metastasis. Their presentation with gynecomastia can be a key clinical clue, differentiating them from the more common germ cell tumors, which rarely cause hormonal symptoms.
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