2,8-dihydroxyadenine (2,8-DHA) crystals appear as brownish, spherical crystals with radial striations under polarized light. They are significant as they indicate adenine phosphoribosyltransferase (APRT) deficiency, a rare autosomal recessive disorder that leads to excessive adenine excretion and crystal-induced nephropathy. These crystals can cause kidney stones and chronic kidney disease. Their presence should prompt evaluation for APRT deficiency, which is treatable with allopurinol and dietary modifications. Distinguishing them from other crystals (like uric acid) is important for diagnosis. This finding highlights the role of urine cytology in detecting rare metabolic disorders.

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Zambia

• Joseph Soko – 101 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies