Sex-Influenced and Sex-Limited Traits
Q: Sex-limited traits are expressed in only one sex, even though the genes may be present in both. True or False?
Did You Know?
This statement is true. The Dombrock blood group system (ISBT 014) antigens (Doᵃ, Doᵇ, etc.) are located on the **ART4 glycoprotein**. ART4 stands for ADP-ribosyltransferase 4 (also known as CD297). While named as a transferase, its enzymatic activity in humans is uncertain. The Do(a-b-) null phenotype is rare and appears to be asymptomatic. Antibodies to Dombrock antigens are often weak and variable but can be clinically significant, causing hemolytic transfusion reactions and mild HDFN.
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