Skin Snip Test for Onchocerciasis
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The Hedgehog pathway is constitutively activated in over 90% of basal cell carcinomas, usually due to loss-of-function mutations in PTCH1 or gain-of-function mutations in SMO. Vismodegib and sonidegib are SMO inhibitors that block this aberrant signaling, providing an effective targeted therapy for advanced or metastatic BCC.
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