Sleep-Wake Disorders and Pharmacotherapy
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Systemic mastocytosis involves excessive mast cell proliferation and release of mediators like histamine. Symptoms are treated with H1 antihistamines (e.g., loratadine) for itching and flushing, and H2 antihistamines (e.g., famotidine) for gastric acid-related symptoms like heartburn. This combination provides broad histamine receptor blockade.
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