The Hedgehog pathway is constitutively activated in over 90% of basal cell carcinomas, usually due to loss-of-function mutations in PTCH1 or gain-of-function mutations in SMO. Vismodegib and sonidegib are SMO inhibitors that block this aberrant signaling, providing an effective targeted therapy for advanced or metastatic BCC.

Break down complex topics into smaller, manageable chunks for easier recall.

Zambia

• loveness Phiri – 1084 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies