Tissue Microarray Technology
Q: How does TMA contribute to effective quality assurance programs in a laboratory, according to the lecture?
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After a radical prostatectomy (surgical removal of the entire prostate), the source of PSA is eliminated, and serum PSA should become undetectable (typically <0.1 ng/mL). A detectable and rising PSA after surgery is called biochemical recurrence (BCR). It is the earliest sign that prostate cancer cells are still present and producing PSA, indicating treatment failure. BCR often precedes clinical or radiographic evidence of metastasis by months to years and triggers decisions about salvage therapies like radiation to the prostate bed or androgen deprivation therapy.
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