Treatment of Onchocerciasis: Ivermectin MDA
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Trichomonas vaginalis is a protozoan, not a bacterium. Common antibiotics like penicillins and cephalosporins are designed to target specific structures or metabolic pathways found in bacteria, such as bacterial cell wall synthesis (peptidoglycan) or protein synthesis on 70S ribosomes. Protozoa like T. vaginalis are eukaryotic cells; they lack a peptidoglycan cell wall and possess 80S ribosomes similar to human cells. Therefore, these antibacterial agents have no target in the parasite and are completely ineffective. Effective treatments for trichomoniasis are antiprotozoal drugs like the nitroimidazoles (metronidazole, tinidazole), which exploit the anaerobic metabolism of the parasite by being reduced to cytotoxic compounds within its cell.
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