The WNT/β-catenin signaling pathway is constitutively activated in the vast majority of colorectal cancers. The initiating event is usually a loss-of-function mutation in the APC tumor suppressor gene, which is considered the 'gatekeeper' of colorectal carcinogenesis. This leads to β-catenin stabilization and uncontrolled transcription of genes driving proliferation.

Break down complex topics into smaller, manageable chunks for easier recall.

Zambia

• loveness Phiri – 1084 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies