University revision · Cellular Pathology

Wax Infiltration, Embedding, and Tissue Orientation

Question 1 of 14 Course: Biomedical Science(Degree)

What is the primary purpose of adding a 'hardener' like beeswax to paraffin wax?

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KSHV encodes v-Cyclin, a viral homolog of cellular cyclin D. v-Cyclin binds to and activates cellular CDK6, promoting phosphorylation and inactivation of the retinoblastoma (pRb) tumor suppressor protein. This pushes the infected cell from G1 into S-phase of the cell cycle, contributing to uncontrolled proliferation seen in KSHV-associated cancers like Kaposi's sarcoma.

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