Tax is the key regulatory protein of HTLV-1. It is a potent transcriptional transactivator that not only drives the expression of viral genes from the viral LTR but also dysregulates numerous host cell genes. It constitutively activates cellular signaling pathways like NF-κB and CREB, inhibits DNA repair and tumor suppressors like p53, and promotes genetic instability, all of which contribute to the development of Adult T-cell Leukemia/Lymphoma (ATLL).

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Zambia

• Joseph Soko – 101 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies