Zinc, Selenium, and Chromium: Trace Element Functions
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Direct oral anticoagulants (DOACs) are a newer class of drugs that directly inhibit specific clotting factors. Rivaroxaban, apixaban, and edoxaban are direct Factor Xa inhibitors. They bind directly to Factor Xa (both free and within the prothrombinase complex), blocking its ability to convert prothrombin to thrombin. Dabigatran is a direct thrombin (Factor IIa) inhibitor. Warfarin indirectly inhibits vitamin K-dependent factors (II, VII, IX, X). Heparin works by enhancing antithrombin. The advantage of DOACs like rivaroxaban is that they have more predictable dosing and do not require routine monitoring with tests like the INR.
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